Fission yeast Srr1 and Skb1 promote isochromosome formation at the centromere
Abstract Rad51 maintains Bike Units - Kids - 24" genome integrity, whereas Rad52 causes non-canonical homologous recombination leading to gross chromosomal rearrangements (GCRs).Here we find that fission yeast Srr1/Ber1 and Skb1/PRMT5 promote GCRs at centromeres.Genetic and physical analyses show that srr1 and skb1 mutations reduce isochromosome fo